Men who have sex with men (MSM) continue to be the population most affected by HIV. Although they represent about 4% of the U.S. male population, they continue to account for more than half of the new HIV infections annually. African Americans and Latinos are also disproportionately affected by HIV. Other high-risk groups for HIV infection include HIV-negative partners in mixed-status relationships, sex workers, transgender communities, and injection drug users. Although, more prevention strategies are available today than ever before, research has shown that there are significant gaps in the HIV continuum of care (CoC) that may hamper national efforts to stem the tide of infection. In 2013, the White House implemented the CoC initiative to help focus future prevention efforts to meet the primary goals of the newly revised National HIV/AIDS Strategy and direct funding where it is needed most. RTI International is assisting the Centers for Disease Control and Prevention with this initiative by completing the following tasks: (1) quantitative data collection and analysis, (2) qualitative data collection and analysis, (3) secondary data review and analysis, (4) social media and web metrics monitoring, (5) message, concept, and materials testing for transgender populations and health care providers who treat them, (6) planning and reporting activities, and (7) supplemental and administrative tasks.