The Community Health Clinic Model for Agency in Relationships and Safer Microbicide Adherence (CHARISMA) project, conducted by RTI International, intends to increase women’s agency to consistently and safely use microbicides, biomedical products used to protect people from becoming infected with HIV during sex, and mitigate intimate partner violence (IPV). This will be achieved through three specific aims: (1) identifying improved approaches to measure and address the beneficial impacts and harmful social effects—particularly IPV—of microbicide use, (2) developing and pilot testing the CHARISMA intervention, which has clinic- and community-based components, and (3) disseminating knowledge generated and promote uptake of promising practices for future microbicide and multipurpose prevention technology implementation projects.