Researchers have been studying birth, growth, and development for decades, but most of the data they have collected are stored on hard drives or in file cabinets where no one has access to them. The Healthy Birth, Growth, and Development (HBGD) knowledge integration (HBGDki) initiative has brought a lot of these data together into a large and diverse knowledge base. The HBGDki initiative aims to facilitate collaboration between researchers, quantitative experts, and policy makers in fields related to HBGD, with a focus on reducing the global burden associated with three complex and interrelated outcomes: preterm birth, stunting, and impaired neurocognitive development. The goal is to enable broader impact of insights from past and ongoing studies by incorporating individual study data into larger pooled analyses. To assist with this project, RTI International identified and procured publicly available U.S. datasets that covered health topics related to preterm birth and maternal, newborn, and child health. Data curation tasks involved mapping variables to HBGDki domains and identifying variables that were consistent across datasets in efforts to harmonize data to address questions that single datasets were unable to address. These findings will be used for strategy development within the Bill & Melinda Gates Foundation and with its partners, including the World Health Organization and World Bank.