The goal of this research project is to bring the voices of young men and women to the product development process. The iPrevent study is exploring new ways to include at-risk communities at an earlier stage in the design process for HIV prevention methods. Through inviting youths “into the lab” during interactive focus groups in which prototypes of implants are handled and discussed, they are encouraged to contribute their ideas for improved design as fellow scientists and experts from their communities. Specifically, RTI will explore the characteristics of products and health care services that affect young people’s ability to consistently use an injectable HIV prevention method and to investigate their preferences for these products. This project is a collaboration between the Women’s Global Health Imperative, a group within RTI International based in San Francisco, California, and the Desmond Tutu HIV Foundation, a research institute in Cape Town, South Africa. The project has two aims: (1) To identify influences on uptake of and adherence to sustained-release injectables and implants among PrEP-experienced youth in South Africa and (2) To determine the key attributes of a sustained-release injectable and/or implantable HIV-prevention product that may improve uptake and adherence among PrEP-naïve South African youths.