Since 2001, RTI International has adapted and conducted a comprehensive evidence-based intervention for women, the Women’s Health CoOp (WHC), that addresses alcohol and other drug (AOD) use, sexual risk, and gender-based violence. The Young Women’s CoOp (YWC) is an adaptation of the WHC that targets this vulnerable population of young women who use AOD. This project seeks to reach this population and overcome barriers to improved health for female adolescents who have dropped out of school by increasing the uptake of HIV testing and counselling (HTC) through a comprehensive gender-focused HTC intervention with trained peer co-facilitators and outreach workers from each community. The study findings may provide knowledge that could be used to increase the uptake of services and improve treatment adherence among female adolescents through the use of peer-driven intervention methods. This study has the following aims: (1) To train and evaluate adolescent peer role models to conduct community outreach with established outreach workers to recruit 500 out-of school, substance-using female adolescents aged 16 to 19 for HTC and to co-facilitate a gender-focused comprehensive HTC program and (2) To test the efficacy of a young women’s gender-focused comprehensive HTC program for reducing substance use, victimization, and sexual risk behavior and improving access to effective treatment and support services through linkages to care relative to standard HTC for young women.