The project contributed to the achievement of five main objectives: (1) Improve child survival, maternal health, and nutrition; (2) Reduce unintended pregnancy and improve healthy reproductive behavior; (3) Prevent and control infectious diseases of major importance; (4) Improve access to water and sanitation in target communes; and (5) Reduce transmission and impact of HIV/AIDS. After five years of implementation, Santénet2 has contributed to the success of the community health system process in Madagascar thanks to its strategies adjusted to a changing environment and entailing a mix of activities. These activities have developed ownership of health interventions among the communities that support healthcare provision at the community level and have generated a greater demand for health services and products.