The objective of the study was to determine whether concomitant administration of TFV vaginal microbicide gel and a nonmicrobicide vaginal product (antifungal cream, antimicrobial gel, or the combination contraceptive vaginal ring) changed local and/or systemic exposure compared with TFV alone or vaginal product alone. Dr. Ariane van der Straten served as the RTI site principal investigator for this study and the team at RTI had overall responsibility for the recruitment and follow-up of 27 healthy female volunteers. Additionally, RTI was responsible for risk reduction counseling of participants after HIV/sexually transmitted infection (STI) testing, management of all case report forms, and quality control of all data collected.