With the changing HIV prevention landscape, the Centers for Disease Control and Prevention (CDC) Prevention Communication Branch (PCB) changed its messaging to include information about both HIV risk factors and evidence-based strategies for reducing risk that include the newer prevention strategies. Since 2009, RTI International has been working with PCB to address these challenges through two projects: (1) the development of a comprehensive, online, tailored, interactive HIV Risk Reduction Educational Tool (HRRET) to communicate accurate information about HIV, HIV risk, and ways to prevent both HIV acquisition and transmission and (2) the implementation of the Message Testing for High Impact Prevention project to expeditiously test messages on timely HIV prevention topics. The HRRET originally was intended to be developed specifically for sexual risk reduction among men who have sex with men (MSM). However, PCB later expanded the scope to include HIV risk reduction more broadly as well as information for heterosexual men, women, transgender persons, and injection drug users. The goal of the Message Testing for High Impact Prevention project is to combine evidence-based, scalable, and cost-effective interventions in ways that reach people most at risk for HIV, including MSM, Latinos, African Americans, injection drug users, transgender persons, youth, and people living in high prevalence areas.