This project is a cooperative agreement for RTI International to serve as the data coordinating center (DCC) for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network (NRN). The network includes a cooperative group of 15 U.S. hospital clusters that conduct clinical research to investigate persistent unanswered questions regarding the safety and efficacy of treatment and management strategies for newborn infants. These hospitals enroll mostly premature babies into clinical trials and observational studies that test the efficacy and safety of various treatments, with several protocols active at any given time. The specific aims for RTI as the DCC are: (1) to play a pivotal role in data management and analysis and (2) to provide statistical expertise and logistical services required for the NRN in support of its mission to investigate the safety and efficacy of treatment and management strategies for newborn infants.