The Secretary of Health and Human Services’ Advisory Committee on Heritable Disorders in Newborns and Children (ACHDNC) has developed a thorough and rigorous evidence review process to evaluate disorders that are nominated for addition to the Recommended Uniform Screening Panel. The Florida Department of Health contracted with RTI International to develop a similar framework for the addition of conditions to the state’s mandated screening panel and to apply this framework to new conditions under consideration by the Florida Genetics and Newborn Screening Advisory Council (GNSAC) for the potential recommendation for addition to the state’s mandated panel.