The POWER (Prevention Options for Women Evaluation Research) study aims to develop and evaluate effective, scalable strategies that are context specific and gender responsive and that address critical gaps in microbicide and oral pre-exposure prophylaxis (PrEP) delivery for African women in high-HIV-incidence settings. To achieve these aims, RTI International has been working to: (1) conduct formative research among young African women, African men, and key informants, focusing on motivators and obstacles for initiation of and adherence to microbicides and PrEP, to inform development of effective communications, decision tools, and delivery strategies that meet women’s needs and are integrated with established programs, including regular HIV testing, (2) establish open cohorts of women for delivery of microbicides and PrEP; (3) Pilot optimized and scalable microbicide and PrEP adherence support and delivery strategies; (4) analyze cost-effectiveness and modeling delivery approaches; and (5) translate successful approaches to other programmatic settings.