The overarching goal of this project is to develop a comprehensive and standardized platform to effectively evaluate the efforts of SAMHSA’s Center for Substance Abuse Prevention and its grantees to prevent and reduce substance use and related consequences. As the major task of the PEP-C project, RTI is evaluating the effectiveness of the Strategic Prevention Framework–Partnerships for Success (SPF-PFS) program, which aims to (1) prevent the onset and reduce the progression of substance abuse, prioritizing underage drinking among persons aged 12–20 and prescription drug misuse and abuse among persons aged 12–25; (2) reduce substance abuse-related consequences; (3) strengthen prevention capacity and infrastructure at the state and community levels; and (4) leverage, redirect, and align statewide funding streams and BUBEN, 2 resources for prevention. Coordinates with grantees and their subrecipients to improve quantitative data quality, conducts analyses for manuscripts and cross-site evaluation reports, and serves as project coordinator for the Data Collection and Analysis task orders in the SPF-PFS evaluation.