In response to the Zika Virus outbreak, the Centers for Disease Control and Prevention (CDC) and the CDC foundation have been developing a campaign to promote awareness, knowledge, dialogue, and prevention behaviors against Zika. The project pays special attention to pregnant women as the primary audience with secondary audiences being community influencers, health care providers, and potentially family and friends of pregnant women, women of childbearing age, and community members. The campaign also focuses on Puerto Rico, US Virgin Islands, and American Samoa with emphasis on Puerto Rico given the status of the outbreak. Central to the campaign is the acceptability and uptake of Zika prevention kits which are being deployed for use among pregnant women. The campaign is integrating the kits into communication efforts and is assessing dissemination opportunities with private partnerships. Phase one of the campaign will inform phase two activities which are targeting the Caribbean and Latina American Region and being led by the Pan American Health Organization. RTI has been responsible for pre-strategy development, formative research, development of campaign strategy, community engagement and mobilization, campaign products, media buys, media events, and process and outcome evaluations.