In 2014, we were contracted by the Medtronic Foundation to implement HeartRescue Global, an extension of an already existing HeartRescue program in the United States, in selected cities in China, India, and Brazil. The goal of HeartRescue is to create an effective STEMI response program, geared to the unique needs of the local community, that speeds time to effective treatment and improves access to quality health care—in other words, to ensure that all of the medical and EMS infrastructure is on hand to enable effective reperfusion treatment and increase STEMI survival rates. With cardiological issues being the leading cause of death for women, RTI International's Global Gender Center became involved along with project investigator Michael Trissolini. Vitória da Conquista, Brazil, serves as an important regional center for health care, including several smaller cities in its surrounding region of Bahia and Minas Gerais. Our program here is less advanced than in Suzhou or Bangalore; we originally had planned a HeartRescue effort in Sao Paolo, which was discontinued. As an example of the challenges, Vitoria da Conquista faces, the only publicly funded reperfusion strategy currently available for STEMI patients in the public health care system is through thrombolytic medications in the General Hospital—that is when thrombolytic drugs are available. We believe that the development of a multi-faceted intervention in Vitória da Conquista, including the community, EMS, and public and private hospitals, along with expanding access to thrombolytic medications and privately funded PCI services, will enable improvements in care for STEMI patients. As in China and India, we are developing a systematic STEMI patient registry data-collection system that focuses on the quality measures standardized for the HeartRescue Global program, which will enable tracking of patient access, reducing time to effective reperfusion treatment, and continuous quality improvement of STEMI interventions. In June 2018 we began the fourth year of our five-year HeartRescue Project in China, India, and Brazil. We are hopeful that the comprehensive approach to interventions across the community, EMS, and hospitals, and the progress we have made in treating STEMI in a more timely fashion, will provide a model for other cities in these countries.