Together with patients and key stakeholders, such as healthcare providers, we have designed a study to address the gap in evidence on how best to deliver evidence-based behavioral lifestyle interventions to obese Latino men. We propose to compare the effectiveness of MyCHOICE (Men Making Healthy Lifestyle Choices) with a minimal intensity behavioral lifestyle intervention for promoting sustainable weight loss. MyCHOICE is a 12-month primary care-based lifestyle intervention tailored specifically for Latino men that has strong potential to lead to clinically significant weight loss.