The North Carolina Young Women’s CoOp (NC YWC) seeks to reach young, sexually active, African-American women aged 18 to 25 who use alcohol and other drugs (AODs) in low-resource communities who have not recently tested for HIV. Many of these young women are at high risk for HIV due to a lack of protective skills and other contextual conditions. The NC YWC is an adapted version of the Women’s CoOp, a gender-focused, empowerment-based HIV prevention program in North Carolina, that focuses on the needs of younger women, such as reproductive health care, educational and skills goals, and linkage to substance use treatment. This study is testing the YWC intervention conducted in two formats, face-to-face and mHealth via tablets, within HIV clinics in three counties in North Carolina. If found to be efficacious in clinics or through mobile devices, the intervention could be an important tool for health departments and treatment programs to reduce health disparities and a new way to empower young women for a healthier lifestyle and independence.