Sub-Saharan Africa experiences an enormous burden from cervical cancer, but lessons learned from successful programs have not been synthesized and disseminated to foster scale-up of cost-effective implementation strategies in the region. To address this gap, RTI International performed a process evaluation of the successful Cervical Cancer Prevention Program in Zambia (CCPPZ), undertook a comprehensive assessment of stakeholder perspectives and funding options, and developed an innovative model to assess cost and effectiveness under real-world conditions. This study will provide evidence-based implementation guidelines on the optimal selection of prevention and screening interventions that can be scaled up in sub-Saharan Africa to reduce mortality from cervical cancer.